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Image Search Results
Journal: Alzheimer's & Dementia
Article Title: Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease
doi: 10.1002/alz.70112
Figure Lengend Snippet: Neuronal ABCA7 deficiency accelerates brain Aβ accumulation in 10‐ to 12‐month‐old 5×FAD mice. (A–C) Quantification of Aβ positivity through immunostaining using pan‐ Aβ antibody in the cortex (B) and hippocampus (C) in 5×FAD control (male, N = 16; female, N = 14) and 5×FAD; n Abca7 −/− mice (male, N = 12; female, N = 10). Scale bars, 500 µm (left) and 50 µm (middle and right) (A). (D–I) Aβ42 and Aβ40 amounts measured by ELISA in TBS, TBSX, and GDN‐HCl fractions of the cortex (D–F) and hippocampus (G–I) from 5×FAD control (male, N = 5 to 16; female, N = 12 to 14) and 5×FAD; n Abca7 −/− mice (male, N = 7 to 12; female, N = 9 or 10). Data are shown in mean ± SEM. Open and closed symbols indicate female and male mice, respectively. * p <0.05, ** p <0.01, and n.s. by two‐way ANOVA test after adjusting for sex. Aβ, amyloid beta; GDN‐HCl, guanidine hydrochloride; n.s., not significant; TBS, tris‐buffered saline; TBSX, Triton X in TBS.
Article Snippet: For oligomeric Aβ measurement, the
Techniques: Immunostaining, Control, Enzyme-linked Immunosorbent Assay, Saline